论文部分内容阅读
在结核病化疗中,利福平+异烟肼(RH)方案中加入此嗪酰胺(Z)可使灭菌效果提高,并可将疗程由9个月缩短至6个月,甚至少于8个月。Z仅在酸性环境有活性,故只对巨噬细胞内酸性环境中的一部分细菌起作用,而对结核空洞壁中性环境中的大量细菌不起作用。当RHZ合用时,如H原始耐药,则大量中性环境中的细菌,仅接受R的作用,从而很易产生耐R的突变菌株。为了避免这一突变,通常需在开始治疗阶段加用第4种药,即乙胺丁醇(E)或链霉素(S)。许多国家所用的简化治疗方案常不包括E或S,仅用RHZ治疗,实践证明效果良好,故设想Z可能有预防耐R茵产生的作用。
In tuberculosis chemotherapy, the addition of this azinamide (Z) to the rifampin + isoniazid (RH) regimen increased sterilization and reduced the duration of treatment from 9 months to 6 months or even less than 8 month. Z is only active in acidic environment, it only plays a role in a part of bacteria in acidic environment in macrophages, but not in a large number of bacteria in the neutral environment of tuberculous walls. When RHZ is used, such as H original resistance, a large number of neutral bacteria in the environment, only accept the role of R, which is easy to produce R-resistant mutant strains. In order to avoid this mutation, it is usually necessary to add a fourth drug, Ethambutol (E) or Streptomycin (S), at the start of treatment. Simplified treatment options used in many countries often do not include E or S, only RHZ treatment, the practice proved good effect, it is assumed that Z may have the role of prevention of Rin production.