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目的 :研究脱氧氟尿苷 (DFUR)冻干粉针剂 (DFURLP)对荷瘤小鼠的抗肿瘤活性。方法 :以荷瘤小鼠的瘤重和生命延长率为指标 ,观察药物 (30 0 ,15 0 ,75mg·kg-1)的抗肿瘤活性。结果 :DFURLP(30 0 ,15 0mg·kg-1,iv)对小鼠移植性肉瘤 180 (S180 )、肝瘤实体型 (Heps)及子宫肉瘤 (U14 )的肿瘤生长具有明显的抑制作用 (P <0 .0 1) ,DFURLP(30 0mg·kg-1,iv)与DFUR(6 0 0mg·kg-1,ig)作用相近 ,DFURLP(30 0 ,15 0mg·kg-1,ip)能显著延长S180 ,Heps,EAC腹水型小鼠移植瘤的存活天数 ,而DFUR(30 0mg·kg-1,ig)对以上 3种腹水瘤无明显延长生命作用。结论 :DFURLPiv及ip对动物实验性肿瘤具有显著的抑制作用。
Objective: To study the anti-tumor activity of DFUR freeze-dried powder injection (DFURLP) on tumor-bearing mice. Methods: The antitumor activity of the drugs (30 0, 150, 75 mg · kg -1) was observed by the tumor weight and the life prolongation rate of the tumor-bearing mice. RESULTS: DFURLP (30 0, 150 mg · kg-1, iv) had a significant inhibitory effect on tumor growth of S180, Heps and U14 in mice (P (0,0.01), DFURLP (30 0 mg · kg -1, iv) had the similar effect with DFUR (600 mg · kg -1, ig) and DFURLP (30 0,15 mg · kg -1, ip) Prolong the survival days of transplanted tumor of S180, Heps and EAC ascites mice, while DFUR (300 mg · kg-1, ig) did not significantly prolong the life span of these three ascites tumors. Conclusion: DFURLPiv and ip have significant inhibitory effects on experimental animal tumors.