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头颈肿瘤对化疗效果较差。多药耐药性（MultidrugResistance，MDR）是肿瘤耐药的主要机理之一。由MDRI基因编码的p-糖蛋白是能量依赖性膜输出泵且在MDR表型中起重要作用。本文对82例未经治疗的鼻咽癌喉癌用免疫组化方法测定p-糖蛋白，并研究了p-糖蛋白表达与化疗、放疗以及临床分期的关系。82例未经治疗的鼻咽癌、喉癌中，53．7％（44／82）p-糖蛋白表达阳性；其中50％（23／46）鼻咽癌和55.6％（20／36）喉癌分别显示出阳性；14例接受化疗的病例其化疗敏感性与p-糖蛋白表达有明显相关性（p＜0．05）；26例接受放疗的肿瘤，其放疗敏感性与p-糖蛋白表达无显著相关关系（P＞0.05）；p-糖蛋白的表达与临床分期亦无显著相关关系．用免疫组织化学方法测定p-糖蛋白可为制订治疗计划和选择适当的抗癌药物提供有用的资料。
Head and neck tumors are less effective in chemotherapy. Multidrug resistance (MDR) is one of the main mechanisms of drug resistance. The p-glycoprotein encoded by the MDRI gene is an energy-dependent membrane output pump and plays an important role in the MDR phenotype. In this paper, 82 cases of untreated nasopharyngeal carcinoma were examined by immunohistochemistry to determine p-glycoprotein, and the relationship between p-glycoprotein expression and chemotherapy, radiotherapy, and clinical staging was studied. Of the 82 untreated nasopharyngeal and laryngeal carcinomas, 53.7% (44/82) were positive for p-glycoprotein; 50% (23/46) of nasopharyngeal carcinoma and 55.6% (20/36) of the larynx Cancers were positive respectively; in 14 patients who received chemotherapy, their chemosensitivity was significantly correlated with p-glycoprotein expression (p<0.05); 26 patients with radiotherapy had radiosensitivity and p-glycoprotein There was no significant correlation between expression (P>0.05); there was no significant correlation between p-glycoprotein expression and clinical stage. The use of immunohistochemistry for the determination of p-glycoprotein may provide useful information for developing treatment plans and selecting appropriate anticancer drugs.