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氟作为一种细胞毒性物质,具有超强的诱导脂质过氧化作用,导致体内自由基蓄积,若不能及时清除,引起一系列连锁反应,最终发生细胞凋亡或坏死。脊髓神经作为神经系统的一部分,氟也可对其造成损伤,氟诱导脊髓神经细胞凋亡的机制尚不明确,因此,本文对此进行了探索。1材料和方法1.1动物分组及处理浙江大学医学院动物中心提供初断乳SD大鼠120只,雌雄各半,驯养1周后,随机分为对照组和低、中、高氟组,每组30只,雌雄分笼饲
As a cytotoxic substance, fluorine has a super-inducing effect on lipid peroxidation, resulting in the accumulation of free radicals in the body. If it can not be removed in time, it causes a series of chain reactions and finally apoptosis or necrosis. As a part of the nervous system, spinal cord nerve can damage the spinal cord through fluorine, and the mechanism of fluorine-induced neuronal apoptosis in spinal cord is not clear. Therefore, this article explores this problem. 1 Materials and methods 1.1 animal grouping and processing Animal Center of Zhejiang University School of Medicine to provide 120 SD rats were weaned, male and female, after one week of domestication, were randomly divided into control and low, middle and high fluoride groups, each group 30, male and female points cage feeding