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钼辅因子作为氧化还原反应中的重要分子,参与硫、氮、碳的氧化还原代谢.钼辅因子主要分为两类:以铁硫簇为基础的铁钼辅因子和以亚钼蝶呤为基础的钼辅因子.钼-二-亚钼蝶呤-鸟苷二核苷钼辅因子(Mo-bis-MGD)是蝶呤型钼辅因子的重要成员之一,是硝酸盐还原酶的重要辅因子.膜结合硝酸盐还原酶介导的硝酸盐还原为细菌提供了氮源和能源,与分枝杆菌的持留性感染相关.此外,膜结合硝酸盐还原酶能显著增加卡介苗在免疫缺陷鼠中的毒性.人与细菌中蝶呤型钼辅因子生物合成、运输和组装的差异提示,Mo-bis-MGD型钼辅因子的生物合成途径很可能作为新型药物靶标,有益于抗病原菌,尤其有利于抗多重耐药结核分枝杆菌新药的开发研究.
Molybdenum cofactor is involved in the redox metabolism of sulfur, nitrogen and carbon as an important molecule in redox reaction. There are two main types of molybdenum cofactors: iron-sulfur cluster-based iron-molybdenum cofactors and molybdenum pterin Basic Molybdenum Cofactor Mo-bis-MGD is one of the important members of the molybdenum cofactor pterin and is important for nitrate reductase Cofactor. Membrane-bound nitrate reductase-mediated nitrate reduction provides a source of nitrogen and energy for bacteria that is associated with mycobacterial persistent infection. In addition, membrane-bound nitrate reductase can significantly increase BCG in immunodeficient mice The differences in the biosynthesis, transport and assembly of the pterin molybdenum cofactors in humans and bacteria suggest that the biosynthetic pathway of Mo-bis-MGD molybdenum cofactors is likely to serve as a novel drug target that is beneficial to anti-pathogenic bacteria, especially Conducive to multi-drug resistant Mycobacterium tuberculosis new drug development and research.