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目的:对高脂血症性胰腺炎的临床特点与诊治方法进行探讨。方法:选取2011年4月~2014年8月之间我院收治的急性胰腺炎患者143例,其中高脂血症性胰腺炎患者35例,将其设为观察组,急性胆源性胰腺炎患者58例,设为观察组,回顾性分析其临床资料,比较病变程度(包括胰腺CT评分、APACHEⅡ评分、Ranson评分和分型),入院时的血、尿淀粉酶含量,以及谷丙转氨酶(ALT)、空腹血糖(GLU)、甘油三酯(TG)的含量,住院时间和预后情况。结果:两组患者的病变程度、住院时间、并发症发生率均无显著差异(P>0.05);对照组患者入院时的空腹血糖、甘油三酯含量均低于观察组,尿淀粉酶、血淀粉酶、谷丙转氨酶的含量均高于观察组,P<0.05,差异显著,具有统计学意义;出院后对照组患者的急性胰腺炎平均发作次数为1.9次,远大于观察组(平均1.2次),P<0.05,差异显著,具有统计学意义。结论:胰腺炎与高甘油三酯症具有密切关联,高脂血症是引起急性胰腺炎的一个重要因素,该类患者的血、尿淀粉酶无明显变化,且发生脂肪肝及糖尿病的几率较高。
Objective: To investigate the clinical features and diagnosis and treatment of hyperlipidemic pancreatitis. Methods: 143 cases of acute pancreatitis admitted to our hospital from April 2011 to August 2014 were selected, including 35 patients with hyperlipidemic pancreatitis. The patients were divided into observation group, acute biliary pancreatitis Fifty-eight patients were enrolled in the study. The clinical data of the patients were retrospectively analyzed. The severity of the disease including pancreatic CT score, APACHEⅡscore, Ranson score and typing were compared. Blood and urine amylase levels, ALT, fasting blood glucose (GLU), triglyceride (TG) content, length of hospital stay and prognosis. Results: There was no significant difference between the two groups in the degree of disease, the length of hospital stay, and the incidence of complications (P> 0.05). The fasting blood glucose and triglyceride levels in the control group were lower than those in the observation group, urine amylase, blood The contents of amylase and alanine aminotransferase in the control group were significantly higher than those in the observation group (P <0.05), with significant difference (P <0.05). The mean number of episodes of acute pancreatitis in the control group after discharge was 1.9, much higher than that in the observation group ), P <0.05, significant difference, with statistical significance. Conclusion: There is a close relationship between pancreatitis and hypertriglyceridemia. Hyperlipidemia is an important factor causing acute pancreatitis. There is no obvious change in blood and urine amylase in these patients, and the incidence of fatty liver and diabetes is higher high.