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采用放射免疫法对25例静脉滴注6mg/kg·d乙基酸霉素(立克菌星)治疗7d的肺炎患儿进行治疗前后尿β_2微球蛋白、尿白蛋白和免疫球蛋白含量测定。结果:治疗前后三项指标的含量分别是755.5±750.5ng/ml、18.1±14.9μg/ml、10.6±7.8μg/ml和206.7±297.2ng/ml、8.6±6.79μg/ml、3.7±1.9μg/ml。与正常对照,治疗前三项指标均明显增高(P<0.01)。治疗后未增高而降低,与用药前相比,差异有显著性意义(P<0.01)。表明推荐剂量短期立克菌星应用于儿童尚未发现肾功能损害。
Radioimmunoassay was used to measure the urinary β_2 microglobulin, urinary albumin and immunoglobulin contents in 25 children with pneumonia treated with intravenous infusion of 6 mg / kg · d (R) for 3 days. . Results: The content of three indexes before and after treatment were 755.5 ± 750.5ng / ml, 18.1 ± 14.9μg / ml, 10.6 ± 7.8μg / ml and 206.7 ± 297.2ng / ml, 8.6 ± 6.79μg / ml and 3.7 ± 1.9μg / ml. Compared with the normal control, the three indexes before treatment were significantly higher (P <0.01). After treatment did not increase and decrease, compared with before treatment, the difference was significant (P <0.01). Show that the recommended dose of short-term use of Rhizoctonia in children has not been found renal damage.