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手足口病是一种常见的小儿传染病。临床以发热、手、足发生皮疹为主要特征,有时还可能出现神经系统的并发症,在国外曾有反复流行,近年来在我国也有流行,但在国内尚缺乏有关该病病原学研究的报道,故我院1984年对31例手足口病病人进行了临床及病原学的研究。此组男15例,女16例,年龄多为6个月～11岁,15例有发热,出现疱疹者27例,丘疹者28例,均呈离心性分布,以手足底为主,口腔粘膜可见疱疹。从此组病人18例皮疱液中用新生小鼠作病毒分离,其中10例标本分离出柯萨奇A16型病毒,21例病人双份血清抗体测定亦证明8例为柯萨奇A16型病毒。此病预后良好。这是我国首次从手足口病病人分离出柯萨奇A16型病毒,这将对本病的诊断和防治研究有重要意义。
Hand, foot and mouth disease is a common pediatric infectious disease. Clinical fever, hand, foot rash as the main features, and sometimes neurological complications may have occurred in other countries have repeated the epidemic in China in recent years are also popular, but there is still a lack of domestic etiology of the disease reported , So our hospital in 1984 31 cases of hand, foot and mouth disease patients were clinical and etiological research. This group of 15 males and 16 females, aged 6 months to 11 years old, 15 cases of fever, herpes zoster in 27 cases, papules in 28 cases, were centrifugal distribution, mainly in the hands and feet, the oral mucosa Shingles visible. From 18 cases of this group of patients with epithelial cells in the newborn mice were used for virus isolation, of which 10 cases were isolated Coxsackie A16 virus, 21 patients with double serum antibody assay also proved 8 cases of Coxsackie A16 virus. The prognosis is good. This is the first time that China has isolated Coxsackie A virus from patients with hand-foot-mouth disease, which will be of great significance in the diagnosis and prevention and treatment of this disease.