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目的合成５-氟尿嘧啶类衍生物。方法用三氯锗基丙酚氯与２，４-二（三甲基硅氧基）-５-氟尿嘧啶反应得到１-（三氯锗基丙酰基）-５-氟尿嘧啶（Ⅰ）．（Ⅰ）经水解即得到其水解产物β-Ｎ１-（５-氟尿嘧啶）甲酰基乙基锗倍半氧化物（Ⅱ）。结果合成了化合物（Ⅰ）和（Ⅱ）。它们的结构由ＩＲ，１ＨＮＭＲ及元素分析确证。
Objective To synthesize 5-fluorouracil derivatives. Methods 1- (trichlorogermanylpropionyl) -5-fluorouracil (Ⅰ) was obtained by reacting trichloro-mesitylpropiophenol with 2,4-bis (trimethylsiloxy) -5-fluorouracil. (I) hydrolyzed to give β-N1- (5-fluorouracil) formyl ethylgermanium sesquioxide (Ⅱ). As a result, compounds (I) and (II) were synthesized. Their structure is confirmed by IR, 1H NMR and elemental analysis.