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幽门螺杆菌(HP)感染很可能是传统冠心病危险因子以外的重要始动因素之一。研究发现只有HP毒力型CagA阳性株与冠心病明显相关。HP感染后,HP毒力型CagA阳性株产生抗CagA抗体。抗CagA抗体与动脉血管壁相关抗原发生交叉反应,启动炎症过程,诱导急性炎性产物的表达和免疫反应,导致血管内皮细胞受损和功能障碍,进而启动动脉粥样硬化的病理演变过程,诱发冠心病发生。
Helicobacter pylori (HP) infection is likely to be one of the important initiators other than the traditional risk factors for coronary heart disease. The study found that only HP virulence CagA positive strains and coronary heart disease was significantly related. After HP infection, HP virulent CagA positive strains produce anti-CagA antibodies. Anti-CagA antibody cross-reacts with arterial wall-associated antigens, initiating inflammatory processes, inducing the expression of acute inflammatory products and immune responses, leading to impaired and dysfunctional vascular endothelial cells, which in turn initiate the pathological progression of atherosclerosis and induce Coronary heart disease occurs.