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目的:分析西宁地区老年人巨幼细胞贫血的临床特点。方法:对56例老年人巨幼细胞贫血住院患者的资料进行分析。结果:老年人巨幼细胞贫血男性多见,男女比例2.2∶1,以头晕、乏力、纳差为主要症状,伴有心脑血管及胃肠道症状者49例(88%),全血细胞减少者40例(71.1%),全部患者均有典型的巨幼红细胞贫血的骨髓像,血清中叶酸或Vit+B12定量减少,用叶酸,Vit+B12治疗效果显著。结论:高原地区老年人巨幼细胞性贫血并不少见,临床应与再生障碍性贫血、骨髓增生异常综合征、溶血性贫血等相鉴别,它的发生与消化道疾病、心脑血管疾病、口腔疾病等相关,应注意病因诊断。
Objective: To analyze the clinical features of elderly megaloblastic anemia in Xining area. Methods: The data of 56 elderly hospitalized patients with megaloblastic anemia were analyzed. Results: Megaloblastic anemia was common in older men, the ratio of male to female was 2.2: 1. Dizziness, fatigue and anorexia were the main symptoms. 49 cases (88%) had cardiovascular and gastrointestinal symptoms, and pancytopenia 40 cases (71.1%), all patients had typical myeloid hyperplasia of megaloblastic anemia, serum folic acid or Vit + B12 quantitative reduction, with folic acid, Vit + B12 significant effect. Conclusion: Megaloblastic anemia in the elderly is not uncommon in the plateau area. It should be differentiated from aplastic anemia, myelodysplastic syndrome, hemolytic anemia and so on. Its occurrence is related to gastrointestinal diseases, cardiovascular and cerebrovascular diseases, Disease and other related, should pay attention to the cause of diagnosis.