骨桥蛋白与牙周病

来源 :武警医学院学报 | 被引量 : 0次 | 上传用户:fanqiefanqie
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骨桥蛋白(osteopontin,OPN)是一种分泌型的糖基化磷蛋白,是骨组织与牙骨质的主要非胶原蛋白分子,由多种细胞合成与分泌,广泛的分布于多种组织与体液中,在骨代谢、炎症反应、创伤愈合、肿瘤转移等多种生理与病理过程中发挥着重要的调节作用,因此,OPN既是一种组织结构分子,又是一种多功能的细胞因子。牙周病发病机制复杂,炎症与牙周支持组织破坏是牙周病特征性的病变。近年来的研究表明,OPN在牙周病的发生、发展及治疗后牙周组织的再生方面起着重要的调节作用。本文就OPN与牙周病有关的生物学功能作一综述。
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