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目的:比较利巴韦林滴鼻与静脉滴注(静滴)治疗感冒的疗效和不良反应。方法:264例门诊病人随机分为滴鼻组138例(男性62例,女性76例;年龄36a±7a),将利巴韦林注射液稀释为10％滴鼻q3～4h。静滴组126例(男性57例,女性69例;年龄38a±9a),将利巴韦林10～15mg.kg~(-1)加于5％葡萄糖注射液500～1000ml中,iv,gtt,qd。结果:2组在用药后1,2,3,4d治愈情况差异无显著意义,P>0.05;不良反应滴鼻组为0例,静滴组为16例(12.7％),差异有显著意义(P<0.05)。结论:利巴韦林滴鼻治疗感冒疗效可靠,无不良反应,优于静滴。
Objective: To compare the curative effect and side effects of ribavirin dripping nose and intravenous drip (intravenous drip) in treating cold. Methods: Two hundred and sixty-four outpatients were randomly divided into nasal instillation group (62 males and 76 females; age 36a ± 7a). The ribavirin injection was diluted to 10% nasal drops q3 ~ 4h. Intravenous group of 126 patients (57 males and 69 females; age 38a ± 9a), ribavirin 10 ~ 15mg.kg -1 added to 5% glucose injection 500 ~ 1000ml, iv, gtt , qd. Results: There was no significant difference in the cure rate of the two groups at 1,2,3,4d after treatment (P> 0.05). There were 0 cases in the nasal drops group and 16 cases (12.7%) in the intravenous drip group, the difference was significant P <0.05). Conclusion: Ribavirin intranasal treatment of cold is reliable, no adverse reactions, better than intravenous infusion.