目的: 探讨雌孕激素对T淋巴细胞生长的调节作用。方法: 将不同浓度的雌孕激素加到Jurkat细胞中培养72h, 用MTT法检测细胞增殖情况; 用DNA片断化分析细胞凋亡情况。结果: 不同浓度的雌孕激素对T淋巴细胞均有抑制作用, 并呈剂量依赖性; 凝胶电泳可见明显的梯状条带。结论: 雌孕激素对T淋巴细胞有直接的抑制作用并诱导细胞凋亡。 Objective: To investigate the regulatory effect of estrogen and progestogen on T lymphocyte growth. Methods: Different concentrations of estrogen and progesterone were added into Jurkat cells for 72 hours. Cell proliferation was detected by MTT assay. Cell apoptosis was analyzed by DNA fragmentation. Results: Different concentrations of estrogen and progesterone inhibited T lymphocytes in a dose-dependent manner. The obvious ladder-like bands were observed by gel electrophoresis. Conclusion: Estrogen and progesterone can directly inhibit T lymphocytes and induce apoptosis.