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目的:利用同步辐射光源成像技术,探索并建立有效、直观的活体大鼠脑微血管高分辨率动态成像体系。方法:采用体重为300~350 g的SD大鼠,经颈动脉插管,注入2种不同对比剂(碘或硫酸钡对比剂)进行成像,调整成像参数,实现在体及活体观察处于正常生理状态下的大鼠脑部微血管结构,确立成像所需的实验条件。结果:硫酸钡适用于大鼠在体血管的观察,非离子型碘对比剂可用于大鼠活体实时脑血管成像。通过实验,基本确立了大鼠活体成像所需参数;采用时间减影法可降低背景及骨骼等对图像的影响。结论:非离子型碘对比剂适用于活体大鼠脑部微血管成像。同步辐射光源是研究活体实验动物脑微血管结构的高分辨率成像手段,将为有效进行活体动物脑部微血管结构观察提供新的方法和途径。
OBJECTIVE: To explore and establish an effective and visual high-resolution dynamic imaging system of brain microvessels in living rat using synchrotron radiation imaging technology. Methods: SD rats weighing 300 ~ 350 g were intubated into the carotid artery and injected with two different contrast agents (iodine or barium sulphate contrast agent) for image formation. The imaging parameters were adjusted to achieve in vivo and in vivo observation in normal physiology State of the rat brain microvascular structure, establishing the experimental conditions required for imaging. Results: Barium sulphate is suitable for the observation of vascular in vivo in rats. The non-ionic iodine contrast agent can be used for real-time real-time cerebral angiography in rats. Through experiments, the basic parameters of in vivo imaging of rat were established. The time subtraction method can reduce the influence of background and bone on the image. Conclusion: Nonionic iodine contrast agent is suitable for brain microvascular imaging in living rats. Synchrotron radiation is a high-resolution imaging method for studying the structure of cerebral microvessels in living animals and will provide a new method and method for effectively observing the microvascular structure in living animals.