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干癣是以表皮细胞的增殖和炎症细胞浸润为特征的慢性难治性皮肤病。其发病机制尚不完全清楚,但免疫抑制剂环孢菌素A(CyA)对重症干癣有显著疗效。这表明以T细胞为主的细胞免疫反应对皮疹形成起很大作用。对CyA已完成有关用药剂量、与甾体激素类外用药的双盲比较以及长期用药试验,并在近期内准备临床治疗重症干癣。另外,临床试用同类药物FK506亦已开始,其有效性逐步得到确认。在干癣病症的形成过程中,细胞因子及致
Psoriasis is a chronic, refractory skin disease characterized by proliferation of epidermal cells and infiltration of inflammatory cells. Its pathogenesis is not fully understood, but the immunosuppressive agent cyclosporin A (CyA) has a significant effect on severe psoriasis. This suggests that T cell-based cellular immune responses play a significant role in the formation of a rash. CyA has completed a double-blind comparison of dosing regimens with topical steroid hormones and long-term medication trials and is preparing for clinical treatment of severe psoriasis in the near future. In addition, the clinical trial of similar drugs FK506 has also begun, and its effectiveness has been gradually confirmed. In the formation of psoriasis disorders, cytokines and induced