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BST-2(Bone marrow stromal antigen 2,BST-2)一种宿主内天然抗病毒因子,自2008年首次报道其具有抗人类免疫缺陷病毒(HIV-1)释放的功能,一直认为BST-2主要在细胞膜上限制病毒释放。最近发现BST-2对在细胞内部组装的乙型肝炎病毒(HBV),同样具有抑制作用,扩大了BST-2抗病毒作用的范围。并且BST-2在多囊泡体(MVB)中抑制HBV的释放与抑制HIV-1在细胞膜中释放的作用机制相似。同时发现HBV能够拮抗BST-2的限制作用,而HBV病毒中发挥作用的拮抗因子,目前有两个观点,一是HBV在肝细胞的特定条件下利用调节蛋白HBx拮抗BST-2的限制作用,另一观点认为包膜蛋白HBs对BST-2存在拮抗作用。本文重点概述和讨论了BST-2限制HBV病毒的最新研究进展。
BST-2 (BST-2) is a natural host anti-viral factor that was first reported in 2008 as having anti-HIV-1 release. It has been considered that BST-2 is mainly Restriction of virus release on the cell membrane. Recently, it was also found that BST-2 also exerts an inhibitory effect on Hepatitis B virus (HBV) assembled inside the cell and expands the range of the antiviral effect of BST-2. And the mechanism by which BST-2 inhibits HBV release in multivesicular vesicles (MVB) is similar to the inhibition of the release of HIV-1 in the cell membrane. At the same time, it was found that HBV can antagonize the inhibitory effect of BST-2, and the antagonist that plays a role in the HBV virus. There are two opinions at present. First, HBV inhibits the inhibitory effect of BST-2 by the regulatory protein HBx under the specific conditions of hepatocytes. Another view that the envelope protein HBs BST-2 antagonism. This article highlights and discusses the recent advances in BST-2-restricted HBV.