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目的研究急性枕叶脑梗死患者视觉皮层中枢脑磁图(MEG)的变化特征。方法对6例急性单侧枕叶梗死表现为对侧视野同向偏盲患者于发病后2周内行视觉诱发磁场(VEFs)测试,并检测8名健康志愿者作为正常对照。刺激选取黑白棋盘格翻转图形。分别记录两组受试者VEFs的M100波峰产生的潜伏期、波形、等电流偶极(ECD)强度和磁源性影像(MSI)。结果所有受试者VEFs反应的最基本波形为M100,位于距状裂两侧的皮质。与正常对照组相比,患者健侧枕叶的VEFs反应波形,潜伏期和ECD强度并无明显差异(均P>0.05),而患侧枕叶的VEF反应则出现了波形异常,潜伏期明显延长和ECD强度显著降低(均P<0.05)异常,且MSI显示其M100反应的ECD位置分布紊乱。结论MEG可检测出急性枕叶脑梗死患者视觉皮质中枢功能的损伤,并能够客观的评价患者视觉皮层中枢的功能状态。
Objective To study the changes of central cerebral magnetization (MEG) in patients with acute occipital lobe cerebral infarction. Methods Visual evoked field (VEFs) tests were performed in 6 patients with acute unilateral occipital lobe infarction and contralateral hemifacial blindness in two weeks after onset. Eight healthy volunteers were tested as normal controls. Stimulate the selection of black and white checkerboard flip graphics. The latencies, waveforms, isoelectric current dipole (ECD) intensity and magnetic source imaging (MSI) of the M100 peak of VEFs in two groups were recorded. Results The most basic waveform of VEFs in all subjects was M100, located in the cortex on both sides of the fissure. Compared with the normal control group, there was no significant difference in the wave shape, latency and ECD intensity of VEFs in the contralateral occipital lobe of patients (all P> 0.05), while the VEF responses of the ipsilateral occipital lobe showed waveform abnormalities with significantly prolonged latency and ECD intensity was significantly lower (all P <0.05) abnormalities, and MSI showed that the M100 response ECD dislocation distribution. Conclusion MEG can detect visual cortical central nervous system injury in patients with acute occipital lobe cerebral infarction and can objectively evaluate the functional status of patients with visual cortex central.