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目的 考察番茄红素对实验性肺纤维化大鼠血浆 TNF-α、NO、MDA含量及 SOD活性的影响。方法 6 0只 SD大鼠随机分为正常对照组 (C组 )、模型组 (M组 )和番茄红素干预组 (L组 ) ,每组各 2 0只。 M组和 L组采用博莱霉素 (BL M)经气管注射建立大鼠肺纤维化模型 ,造模当日起 L组每天用番茄红素油树脂灌胃 ,3、7、14和 2 8d处死大鼠采集血浆 ,测定 TNF-α、NO、MDA含量及 SOD活性。结果 与 M组相比 ,L组各时间段 TNF-α、NO、MDA含量降低 (7、14、2 8d,TNF-α:P<0 .0 1;3d,NO、MDA:P<0 .0 5 ) ,SOD活性增高 (2 8d,P<0 .0 5 )。结论 番茄红素能够降低实验性肺纤维化大鼠血浆 TNF-α、NO、MDA含量 ,提高 SOD活性 ,对博莱霉素致大鼠的肺损伤具有一定保护作用
Objective To investigate the effect of lycopene on plasma TNF-α, NO, MDA content and SOD activity in experimental pulmonary fibrosis rats. Methods Sixty SD rats were randomly divided into normal control group (C group), model group (M group) and lycopene intervention group (L group), with 20 rats in each group. Group M and group L were treated with bleomycin (BL M) via tracheal injection to establish rat model of pulmonary fibrosis. Group L was orally administered with lycopene oleoresin on the day of modeling, and sacrificed on days 3, 7, 14 and 28 The plasma was collected and the content of TNF-α, NO, MDA and SOD activity were measured. Results Compared with M group, the levels of TNF-α, NO and MDA in L group were decreased at 7, 14 and 28 days (P <0.01). 0 5), SOD activity increased (28d, P <0.05). Conclusions Lycopene can reduce the content of TNF-α, NO and MDA in plasma and increase the activity of SOD in experimental pulmonary fibrosis in rats, which may have a protective effect on bleomycin-induced lung injury in rats