自开创小鼠淋巴细胞杂交瘤技术以来关于B细胞的哪一个分化阶段参与融合并形成具有分泌抗体功能的杂交瘤,至今没有定论。由于B细胞分化各个阶段尚无统一标准,同时由免疫母细胞转变成浆细胞的过程中尚有多种形态表现,从而给统一认识带来困难。本文拟 Since the initiation of the mouse lymphocyte hybridoma technology, it has not been elucidated to which fusion stage of B cells to participate in the fusion and to form a hybridoma that secretes antibodies. As B cells do not have a uniform standard in all stages of their differentiation, and there are many morphological changes in the process of transformation from immunoblasts to plasma cells, which makes it difficult to achieve a unified understanding. This article is intended