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早在1883年Sidney Ringer就已认识到心肌收缩与钙有关。1964年Fleckenstein首先发现异搏定对心脏具有抑制作用,1977年他又阐明了此种抑制效应与慢钙内向电流受阻有关。二十余年来,钙内流阻滞剂被广泛用于治疗各种类型心绞痛,反复发作性室上性心动过速等,疗效卓著。近来又被成功地控制高血压,且可能成为高血压的一线用药。为了更好地开发、利用这一类药物,现就其临床应用方面的新近状况作一简要介绍。
As early as 1883, Sidney Ringer realized that myocardial contractility is related to calcium. Fleckenstein first discovered in 1964 that verapamil had an inhibitory effect on the heart. In 1977, he also clarified that this inhibitory effect was related to the inhibition of the inward current of slow calcium. More than 20 years, calcium blockade agents are widely used in the treatment of various types of angina, recurrent supraventricular tachycardia, etc., with remarkable efficacy. Has recently been successfully controlled hypertension, and may become a first-line treatment of high blood pressure. In order to better develop and utilize this kind of medicine, a brief introduction on the recent situation in clinical application is given.