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目的:观察PET/CT对非小细胞肺癌(NSCLC)三维适形放疗(3D-CRT)中治疗计划参数的影响。方法:对83例在PET/CT定位下拟行根治性3D-CRT的NSCLC患者,分别以CT图像和PET/CT融合图像勾画大体肿瘤靶区(GTVCT和GTVPET/CT),分别制定放疗计划,并对两者进行比较。结果:PET/CT明显改变44例(53.01%)患者GTV或PTV,31例PTV和(或)GTV减小,13例PTV和(或)GTV增加。根据PET/CT和CT分别制定的放疗计划在VGTV、VE50、SCM和ESM的差异有统计学意义,P值分别为0.001、0.001、0.000和0.002。结论:应用PET/CT制定NSCLC3D-CRT治疗计划可降低食管和脊髓的受照射剂量,从而有利于放疗剂量的提升。
Objective: To investigate the effect of PET / CT on the planning parameters in 3D-CRT of non-small cell lung cancer (NSCLC). Methods: Totally 83 patients with NSCLC undergoing PET-CT with targeted 3D-CRT were enrolled in this study. The gross tumor targets (GTVCT and GTVPET / CT) were sketched with CT images and PET / CT images respectively, And compare the two. Results: PET / CT significantly changed GTV or PTV in 44 patients (53.01%), decreased PTV and / or GTV in 31 patients and increased PTV and / or GTV in 13 patients. The difference of VGTV, VE50, SCM and ESM between radiotherapy plans based on PET / CT and CT was statistically significant with P values of 0.001, 0.001, 0.000 and 0.002, respectively. Conclusion: The application of PET / CT to develop the NSCLC3D-CRT treatment plan can reduce the dose of esophageal and spinal cord irradiation, which is conducive to the improvement of radiation dose.