论文部分内容阅读
目的：探讨胰岛素中枢直接保护作用对全脑缺血后大鼠学习记忆力改变的影响。方法：在全脑缺血再灌注后即刻腹腔注射１Ｕ／ｋｇ胰岛素，于缺血后８周利用“Ｙ”型迷宫测试大鼠的学习记忆功能，并对大鼠海马ＣＡ１区正常神经进行计数。结果：缺血组大鼠学习记忆力明显下降，海马ＣＡ１区正常神经元计数治疗组明显高于缺血组。结论：全脑缺血再灌注后使用胰岛素可明显减轻大鼠的学习记忆力损害，其作用基础在于减少海马ＣＡ１区神经元坏死，并有中枢直接保护作用。
Objective: To investigate the effect of direct insulin protection on learning and memory in rats after global cerebral ischemia. Methods: 1U / kg insulin was injected intraperitoneally immediately after global cerebral ischemia / reperfusion and the learning and memory function of rats was tested by “Y” maze 8 weeks after ischemia. The normal nerves in hippocampal CA1 area of rats were counted. Results: The learning and memory abilities of ischemic rats decreased significantly, and the number of normal neurons in hippocampal CA1 area was significantly higher than that of ischemic group. Conclusion: The use of insulin after global cerebral ischemia / reperfusion can significantly reduce the learning and memory impairment in rats, and its effect is based on the reduction of neuronal necrosis in the hippocampal CA1 region and the direct central protection.