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目的:观察胺碘酮治疗乌头碱急性中毒所致严重室性心律失常的疗效。方法:选择因乌头碱急性中毒导致严重室性心律失常116例,随机分为胺碘酮组60例和利多卡因组56例,两组均给予常规治疗,在此基础上,胺碘酮组给予盐酸胺碘酮静脉滴注负荷量后以1～1.5 mg/min静脉滴注;利多卡因组给予盐酸利多卡因,负荷量后继以1～2 mg/min静脉滴注维持。观察用药30 min、6 h4、8 h后两组治疗有效率及肌酸激酶同工酶(CK-MB)水平的改善。结果:用药30 min和6 h后两组抗心律失常有效率差异不显著(P>0.05),48 h后胺碘酮组有效率显著高于利多卡因组(P<0.05);胺碘酮组CK-MB升高者用药30 min6、h4、8 h后治疗有效率均显著或非常显著高于利多卡因组(P<0.05,P<0.01)。结论:胺碘酮治疗乌头碱中毒所致严重室性心律失常,短期疗效与利多卡因相当,48 h后疗效优于利多卡因。
Objective: To observe the efficacy of amiodarone in the treatment of severe ventricular arrhythmia caused by aconitine acute poisoning. Methods: One hundred and sixty-six cases of severe ventricular arrhythmia caused by aconitine acute poisoning were randomly divided into amiodarone group (n = 60) and lidocaine group (n = 56). Both groups were given routine treatment. On the basis of this, amiodarone The patients were given intravenous infusion of amiodarone hydrochloride intravenously at a dose of 1 ~ 1.5 mg / min, lidocaine hydrochloride was given at a dosage of 1 ~ 2 mg / min intravenously in the lidocaine group. After treatment for 30 min, 6 h and 8 h, the therapeutic efficacies and the creatine kinase (CK-MB) levels in both groups were improved. Results: After 30 min and 6 h, the effective rate of antiarrhythmic in both groups was not significantly different (P> 0.05), and the effective rate of amiodarone group was significantly higher than that of lidocaine group after 48 h (P <0.05) The effective rate of treatment of group CK-MB elevated 30 min 6, h 4 and 8 h after treatment was significantly or very significantly higher than that of lidocaine group (P <0.05, P <0.01). Conclusion: Amiodarone treatment of aconitine poisoning caused by severe ventricular arrhythmias, short-term efficacy and lidocaine quite effective after 48 h better than lidocaine.