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目的比较不同剂量卡培他滨治疗老年转移性乳腺癌的临床疗效。方法选取赣州经济技术开发区蟠龙镇中心卫生院2014年1月—2016年1月收治的老年转移性乳腺癌患者56例,随机分为对照组和观察组,各28例。对照组患者采用大剂量卡培他滨治疗,观察组患者采用中等剂量的卡培他滨,两组患者均最多服药6个疗程。比较两组患者临床疗效及毒副作用发生情况。结果两组患者治疗有效率、病情控制率比较,差异无统计学意义(P>0.05)。观察组患者Ⅰ和Ⅱ度手足综合征、Ⅰ和Ⅱ度骨髓抑制、Ⅰ度腹泻、Ⅰ度消化道反应发生率低于对照组(P<0.05)。结论中等剂量与大剂量卡培他滨治疗老年转移性乳腺癌的临床疗效相当,但中等剂量卡培他滨单药治疗更具安全性。
Objective To compare the curative effect of different doses of capecitabine in the treatment of elderly patients with metastatic breast cancer. Methods Fifty-six elderly patients with metastatic breast cancer who were admitted to Beilong Center Central Hospital, Ganzhou Economic and Technological Development Zone from January 2014 to January 2016 were randomly divided into control group and observation group, with 28 cases in each group. Patients in the control group received high-dose capecitabine, and patients in the observation group received capecitabine in moderate doses. Both groups took up to 6 courses of treatment. The clinical efficacy and side effects of the two groups were compared. Results The two groups of patients with treatment efficiency, disease control rate, the difference was not statistically significant (P> 0.05). The observation group Ⅰ and Ⅱ degree hand-foot syndrome, Ⅰ and Ⅱ degree myelosuppression, Ⅰ degree diarrhea, Ⅰ degree digestive tract reaction was lower than the control group (P <0.05). Conclusions The middle-dose and high-dose capecitabine are effective in the treatment of elderly patients with metastatic breast cancer, but the moderate-dose capecitabine monotherapy is more safe.