根据电子等排原理,合成了5个2,4-二氨基-5-烷氧基苯氨嘧啶类化合物,它们对大肠杆菌1515的抗菌活性均弱于TMP。与以前合成的20个化合物一起进行Hansch相关分析,结果表明抑菌作用与取代基的MR呈线性相关。2-位取代基与3,4-位及5-位取代基对化合物抑菌活性的贡献各不相同。 Five 2,4-diamino-5-alkoxyaniline compounds were synthesized based on the principle of electronic isotype. Their antibacterial activity against E. coli 1515 was weaker than that of TMP. Hansch correlation analysis with 20 previously synthesized compounds showed that the antibacterial activity was linearly related to the MR of the substituents. The contribution of the 2-position substituent to the 3, 4-position and 5-position substituents varies from the bacteriostatic activity of the compound.