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对１７例已发生多器官衰竭（ＭＯＦ）的患者，于发病后第１～２０天分别进行血浆肿瘤坏死因子（ＴＮＦ）与纤维连结蛋白（ｆｎ）的动态观测。结果：①全部患者病程各时间点的血浆Ｆｎ均值均低于正常值（２５２．１２±２４．７２ｍｇ／Ｌ），ＴＮＰ均值则明显高于正常值（５．５０±０．２７ｕｇ／Ｌ）。②ＭＯＦ发生５天内Ｆｎ均值波动下降，第６天有明显回升达正常界限，第７天降低后再度明显回升，但于第１０天又见下降而后波动在１８０．００～２３０．００ｍｇ／Ｌ。③ＴＮＦ均值在ＭＯＦ发生５天内逐日上升，达到４５．００１ｕｇ／Ｌ，而后虽有一定波动，但基本持续在３２．００ｕｇ／Ｌ以上。作者认为：与正常人比较，ＴＮＦ的增高变化比Ｆｎ降低变化更为明显，且较稳定，故作为诊断参考指标１ＮＦ比Ｆｎ更有价值。
In 17 patients with multiple organ failure (MOF), dynamic changes of plasma tumor necrosis factor (TNF) and fibronectin (fn) were observed on the 1st to 20th days after onset. Results: ① The mean plasma Fn levels were lower than normal (252.12 ± 24.72mg / L) and TNP mean values were significantly higher than normal (5.50 ± 0.27ug / L) at all time points. (2) FN mean fluctuation fluctuated within 5 days after MOF, and it returned to the normal level on the 6th day. It recovered again on the 7th day, but decreased on the 10th day and then fluctuated between 180.00-230.00 mg / L. (3) The average value of TNF increased daily within 5 days of MOF, reached 45.001ug / L, and then it fluctuated, but continued to be above 32.00ug / L. The authors think: compared with normal people, changes in TNF increased more significantly than the Fn decrease, and more stable, so as a diagnostic reference index 1NF more valuable than Fn.