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目的 :评价肝癌标志物多项联合检测对原发性肝癌 (PHC)的诊断价值。方法 :选择PHC 41例、良性肝病 10 3例及 45名健康人进行血清α L 岩藻糖苷酶 (AFU)和低密度脂蛋白与极低密度脂蛋白结合的γ 谷氨酰转肽酶 (LDL VLDL GGT)测定 ,并与甲胎蛋白 (AFP)联合检测。结果 :AFP、AFU、LDL VLDL GGT对PHC的敏感性分别是 73.2 %、78.0 %、43.9% ,特异性分别是 89.9%、95 .9%、99.3%。PHC患者血清中AFU、LDL VLDL GGT活力与AFP含量之间均无明显关系。结论 :二联或三联检测可提高PHC诊断的准确性 ,特别有利于防止AFP阴性的PHC患者漏诊。
Objective: To evaluate the diagnostic value of multiple combined detection of hepatocellular carcinoma markers on primary liver cancer (PHC). Methods: 41 cases of PHC, 10 3 cases of benign liver disease and 45 healthy individuals were enrolled in this study. Serum α-L-fucosidase (AFU) and γ-glutamyl transpeptidase (LDL) combined with LDL VLDL GGT) and combined with AFP (AFP). Results: The sensitivities of AFP, AFU and LDL VLDL GGT to PHC were 73.2%, 78.0% and 43.9% respectively, and their specificity were 89.9%, 95.9% and 99.3% respectively. There was no significant relationship between serum AFU, LDL VLDL GGT activity and AFP content in PHC patients. Conclusions: Two- or three-line detection can improve the accuracy of PHC diagnosis and is especially helpful for preventing missed diagnosis of AFP-negative PHC.