生物膜是细菌或真菌附着于物体表面所形成的有一定结构和功能的菌细胞群体,其最显著的特征之一是高度耐药性,单用一种抗菌药物很难将其完全清除,而不同种类药物的联合应用可有效清除生物膜。本文现就近年来针对铜绿假单胞菌、葡萄球菌、大肠杆菌、白念珠菌等常见病原菌生物膜的药物协同干预作用作一综述。 Biofilm is a bacteria or fungi attached to the surface of the body formed by a certain structure and function of bacterial cell populations, one of the most salient features is highly resistant, with an antimicrobial drugs is difficult to completely remove it, and The combination of different types of drugs can effectively remove the biofilm. In this paper, we review the synergistic effects of drugs on the biofilms of common pathogenic bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Candida albicans in recent years.