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既往研究认为慢性溃疡性结肠炎(简称溃结)有较高的结肠癌发病率,而结肠粘膜上皮发育异常是一种癌前病损。本文对23例慢性溃结伴结肠癌者和57例溃结无结肠癌的手术切除标本作了回顾性分析,另对36例慢性溃结、12例结肠 Crohn 氏病和12例其它胃肠道疾病患者作前瞻性研究,以图了解溃结患者结肠上皮发育异常的程度及与结肠癌的关系,结果如下。回顾组:23例慢性溃结伴癌肿者,溃结的发病年龄为10～51(平均24)岁,病程为8～40(平均21)年,发生结肠癌的平均年龄为44(26～62)岁,5例(22%)由溃结发展至癌肿相隔为10年或以下(8～10年)。23例中22例为全结肠炎,1例为直肠乙状结肠炎。共发生结肠癌肿29处(6例有2处病变),其中19处呈息肉样或蕈状,5处结肠粘膜表面呈扁平
Previous studies suggest that chronic ulcerative colitis (referred to as ulceration) have a higher incidence of colon cancer, and colonic mucosal epithelial dysplasia is a precancerous lesions. In this paper, we retrospectively reviewed 23 cases of chronic ulcerative colitis and 57 cases of ulcerative colitis without colorectal cancer. Thirty-six cases of chronic ulcer, 12 cases of Crohn’s disease and 12 cases of other gastrointestinal diseases Prospective study of patients in order to understand the degree of ulceration in patients with colonic epithelial dysplasia and colon cancer, the results are as follows. In the retrospective group, 23 patients with chronic ulceration and cancer were found. The age of onset of ulceration was 10-51 (mean 24 years), and the course of disease was 8-40 (average 21) years. The average age of colon cancer was 44 ) Years old, 5 cases (22%) developed from ulceration to cancer separated by 10 years or less (8 to 10 years). Twenty-three of the 23 patients had total colitis and 1 had rectal sigmoiditis. There were 29 colon cancer cases (6 lesions in 2 cases), of which 19 were polypoid or mushroom-like, and 5 colon mucosa surfaces were flat