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目的：比较达克罗宁胶浆与利多卡因喷喉对气管插管和拔管时血压、心率的影响，以及患者术后咽喉痛的影响。方法全麻择期妇科腹腔镜手术患者100例，年龄25~65岁，体重40~65kg，ASA分级I~II级，Mallampati分级0.05）。两组拔管时呛咳、躁动及术后咽喉痛等比较亦无明显统计学意义（>0.05）。结论利多卡因喷喉组与盐酸达克罗宁胶浆组在抑制插管时心血管反应，减轻气管导管拔除时的呛咳、屏气及咽喉痛等不适方面无差异。“,”Objective To compare dyclonlne and lidocaine on the inhibitory effect of cardiovascular response during endotracheal intubation and extubation, and on alleviating postoperative sore throat.Methods One hundred patients (aged 25~65 years,weighing 40~65kg,American Society of Anesthesiologists grade I or II) undergoing elective gynecological laparoscopic surgery under standard general anaesthesia were enrolled in this prospective, double-blind and controlled study and randomized into two groups:dyclonine group and lidocaine group.The equal amounts of dyclonine hydrochloride and paraffin oil were evenly painted at end of the endotracheal tube before intubation in group D and L,respectively.and in group L 2%lidocaine was sprayed 2min before intubation. Both groups used the UE scope video laryngoscope to intubate. The operation time, intraoperative sufentanyl and dexmedetomidine consumption were recorded in both groups. Furthermore, heart rate (HR), systolic blood pressure(SBP),diastolic blood pressure (DBP)were measured. Moreover, sore throat complications were observed 2 days after operation. Results There were no significant difference in the HR, SBP, DBP and sore throat complications between the two groups ( >0.05).Conclusion Dyclonine hydrochloride and lidocaine spray has no difference in the application of endotracheal intubation.