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目的 对比观察比索洛尔和美托洛尔治疗轻、中度高血压患者的临床疗效与安全性。方法 采用随机、开放、平行对照方法 ,观察比索洛尔 (n =1 1 5)每日 2 5～ 7 5mg或加双氢克尿噻 1 2 5mg,美托洛尔 (n =1 0 5)每日 50～ 1 50mg或加双氢克尿噻 1 2 5mg治疗 6周和 8周的有效率。 结果 两组治疗第 2周开始平均收缩压 (SBP)、舒张压(DBP)和心率 (HR)较治疗前均明显降低 (P <0 0 1 ) ;在整个治疗期间血压和HR持续平稳下降 ,治疗后 2～ 8周血压下降值比索洛尔组为 1 1 0 / 8 6～ 2 1 6/ 1 6 2mmHg ,美托洛尔组为 1 1 0 / 8 8～ 1 6 7/ 1 4 9mmHg ;HR下降值前组为5 1～ 8 9次 /分 ,后组为 4 8～ 7 3次 /分 ;服药第 8周比索洛尔组降低SBP优于美托洛尔组 (P <0 0 1 ) ,其它两组间比较无明显差异 (P均 >0 0 5)。比索洛尔和美托洛尔治疗 6周降低血压的总有效率分别为 84 3 %和 79 0 % (P >0 0 5) ;8周加双氢克尿噻总有效率分别为 91 3 %和 81 0 % (P <0 0 5) ,比索洛尔加利尿剂可组提高降压疗效 7%。动态血压监测 (ABPM)显示比索洛尔降低夜间SBP优于美托洛尔 (P <0 0 1 ) ;比索洛尔T/P比值 >50 %。结论 比索洛尔是一种有效、高选择性 β1 受体阻滞的长效降压药 ,副作用轻微 ,耐受性好。联合应用小?
Objective To compare the clinical efficacy and safety of bisoprolol and metoprolol in patients with mild to moderate hypertension. Methods A randomized, open and parallel controlled study was conducted to observe the effects of bisoprolol (n = 115) daily from 25 to 75 mg or hydrochlorothiazide 125 mg and metoprolol (n = 105) Daily 50 ~ 150mg or hydrochlorothiazide 125mg treatment of 6 weeks and 8 weeks of the efficiency. Results The mean systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) in the two groups at the second week of treatment were significantly lower than those before treatment (P <0.01); during the whole treatment period, the blood pressure and HR continued to decline steadily, After 2 to 8 weeks of treatment, the decrease in blood pressure was between 110/86 and 216/162 mmHg in the bisoprolol group and between 110 and 88-167 / 1409 mmHg in the metoprolol group. In the 8th week after taking bisoprolol, SBR was lower than that of metoprolol group (P <0.01), and HR of the former group was 51 ~ 89 times / min and the latter group was 48 ~ 73 times / ), No significant difference between the other two groups (P> 0.05). The total effective rates of bisoprolol and metoprolol in lowering blood pressure after 6 weeks treatment were 84 3% and 79 0% respectively (P 0 05). The total effective rates of HBO and HBT were 91 3% and 81 0 % (P <0.05), bisoprolol plus diuretic group can improve antihypertensive effect of 7%. Ambulatory blood pressure monitoring (ABPM) showed that bisoprolol reduced nighttime SBP over metoprolol (p <0.01); and bisoprolol T / P ratio was> 50%. Conclusion Bisoprolol is a long-acting antihypertensive drug with potent and highly selective β1 receptor blocker with mild side effects and good tolerability. Joint application of small?