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目的探讨相关抗体阴性类风湿关节炎(rheumatoid arthritis,RA)的临床资料特点。方法分析493例RA患者,比较相关抗体抗体阴性RA(35例)与抗体阳性RA临床资料特点,以一般情况的RA作为对照。结果相关抗体阴性的RA占7.10%(35/493),相关抗体阴性RA患者的血沉较自身抗体阳性RA患者低(p<0.05);年龄、病程、晨僵时间、关节触痛数、关节肿胀数、及DAS28评分均无明显差异(p>0.05)。结论RA患者中相关抗体阴性者占7.10%,提示自身抗体阴性RA并不少见。对于已确诊的相关抗体阴性的RA患者应给予积极的治疗。
Objective To investigate the clinical data of rheumatoid arthritis (RA) related antibody negative. Methods A total of 493 RA patients were analyzed. The clinical data of RA-positive RA patients (35 cases) and RA-positive RA patients were compared. The RA patients were used as controls. Results RA of negative antibody correlated with the antibody titer was 7.10% (35/493). The erythrocyte sedimentation rate of RA patients with negative antibody was lower than that of autoantibody positive RA patients (p <0.05). The age, course of disease, morning stiffness, joint tenderness, Number, and DAS28 scores were no significant difference (p> 0.05). Conclusions The related antibody negative in RA patients accounted for 7.10%, suggesting that autoantibody negative RA is not uncommon. Active RA should be given to RA patients who have been diagnosed as having negative antibodies.