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后代中新生的染色体结构畸变的原因很多,对其父亲进行精子细胞遗传学分析对于探讨畸变的病因及确定再发风险都有重要的意义。本研究是通过G带染色及双色荧光原位杂交的方法对1例平衡易位患儿t(11;15)(q12;q 22)的父亲精子进行分析,以确定其结构畸变率是否比对照组增加。 患儿经羊膜穿刺后被确诊是t(11;15)(q12;q 22),父母基因型正常。其父亲精液未接触任何不利因素。他的精子中期染色体是在试管中将田鼠卵细胞与他的精子相混合后获得的。然后对其进行连续分析,即先用
There are many reasons for the chromosome aberrations in the offspring. There are many reasons for the sperm cytogenetic analysis of their father to explore the etiology of the distortion and determine the risk of recurrence. In this study, we analyzed the sperm of t (11; 15) (q12; q22) father in a balanced translocation by G-band staining and two-color fluorescence in situ hybridization to determine if the structural aberration rate was higher than that of the control Group increase. Children were confirmed by amniocentesis t (11; 15) (q12; q22), the normal parental genotype. The sperm of his father did not come into contact with any unfavorable factors. His sperm metaphase is obtained by mixing the voles in the test tube with his sperm. Then carry on the continuous analysis to it, namely use first