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目的 探讨噪声作业工人血浆热应激蛋白 (HSP) 70抗体与心功能异常之间的关系。方法 用Westernblot免疫印迹法测定噪声作业工人血浆HSP70抗体水平 ,用多因素Logistic回归模型分析HSP70抗体水平与心电图异常的关系。结果 心电图异常组HSP70抗体阳性率为 3 5 6% ,明显高于心电图正常组 (15 7% ) ;在排除了常见心血管疾病危险因素的影响后 ,心电图异常与HSP70抗体之间仍然存在较强联系。结论 血浆HSP70抗体可能是噪声作业工人心脏功能异常的危险因素之一。
Objective To investigate the relationship between plasma heat stress protein (HSP) 70 antibody and cardiac dysfunction in noise workers. Methods Western blot was used to determine the level of plasma HSP70 antibody in noise workers. The relationship between HSP70 antibody levels and ECG abnormalities was analyzed by multivariate logistic regression model. Results The positive rate of HSP70 antibody in ECG abnormal group was 35.6%, which was significantly higher than that in normal ECG group (15.7%). After eliminating the influence of common cardiovascular disease risk factors, there was still strong between ECG abnormality and HSP70 antibody contact. Conclusions Plasma HSP70 antibody may be one of the risk factors of cardiac dysfunction in noise workers.