目的评价五种肿瘤标志物联合检测对消化道肿瘤诊断的价值。方法 373例消化道肿瘤患者作为观察组,206例消化道非肿瘤作为对照组,检测患者的血清肿瘤标志物。甲胎蛋白(AFP)、癌胚抗原(CEA)、血清铁蛋白(SF)为酶联免疫吸附试验(ELISA)定量法,消化道癌抗原(CCA)为ELISA两步定性法,唾液腺(SA)为快速比色法。结果 1观察组与对照组组的肿瘤五项指标单项检测:敏感性和特异性AFP为14.50%和94.17%;CEA为13.70%和94.66%;SF为26.80%和69.42%;CCA为10.50%和96.60%;SA为47.20%和68.45%。2肿瘤标志物联合检测结果:四项同时阳性敏感性1.70%,特异性100.00%;二项以上阳性敏感性、特异性分别为31.90%和85.00%,而仅一项阳性敏感性特异性分别为67.50%和65.50%。结论肿瘤五项联合检测降低了单一指标检测产生的假阳性和假阴性,能简便有效协助临床在较早期诊断,在高危人群普查以及疗效监控方面发挥作用,为癌前病变及术后治疗评价提供可靠的依据。 Objective To evaluate the value of combined detection of five tumor markers in the diagnosis of gastrointestinal tumors. Methods A total of 373 patients with gastrointestinal cancer as observation group and 206 patients with gastrointestinal non-tumor as control group were enrolled in the study. Serum tumor markers were detected in these patients. AFP, CEA and SF were quantified by enzyme-linked immunosorbent assay (ELISA), digestive tract cancer antigen (CCA) by two-step ELISA, salivary gland (SA) For rapid colorimetry. Results 1 The detection of the five indicators of tumor in the observation group and the control group were single detection: the sensitivity and specificity of AFP was 14.50% and 94.17%; CEA was 13.70% and 94.66%; SF was 26.80% and 69.42%; CCA was 10.50% and 96.60%; SA was 47.20% and 68.45%. The results of combined detection of tumor markers: 1.The positive rate of the four positives was 1.70% and the specificity was 100.00%. The positive rate of the two or more positives was 31.90% and 85.00% respectively, but only one positive sensitivity was 67.50% and 65.50%. Conclusions The five joint detection of tumor reduces the false positive and false negative produced by single index test. It can help clinical diagnosis easily in an earlier stage, and plays an important role in monitoring of high risk population and monitoring of curative effect. It provides the evaluation for precancerous lesions and postoperative treatment Reliable basis.