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自1899年Metchnikoff研究精子毒素(即精子抗体),男性生殖免疫学的发展已有90年的历史。虽然1954年美国的wilson和荷兰的Rumke提出了精子自身免疫的概念,并很早进行探讨男子不育与免疫的关系,寻找各种治疗免疫性不育的方法,但是,至今男性免疫性不育依然是个难题。男性不育8—10%与免疫因素有关。原因不明的不育夫妇中,10%是免疫因素所致。Fjallbrant报道不育男子中有7%可在血或精液中查到抗精子抗体,梗阻性无精症中,有抗精抗体者高达60%。Rumke进行的前瞻性研究结果表
Since 1899 Metchnikoff studies sperm toxins (ie sperm antibodies), the development of male reproductive immunology has been 90 years old. Although Wilson in the United States in 1954 and Rumke in the Netherlands proposed the concept of sperm autoimmunity and discussed the relationship between male infertility and immune as early as possible, looking for various ways to treat immune infertility. However, so far male autoimmune infertility Still a problem. Male infertility 8-10% and immune factors. In unexplained infertility couples, 10% is caused by immune factors. Fjallbrant reports that 7% of infertile men can detect anti-sperm antibodies in blood or semen, and up to 60% have anti-sperm antibodies in obstructive azoospermia. Rumke’s prospective study results table