主要组织相容性复合体(major histocompatibility complex,MHC)是由一系列紧密连锁的基因座位所组成的具有高度多态性的复合体,人类MHC又称人类白细胞抗原(human leukocyte antigen,HLA)。HLA参与免疫反应,与多种疾病有关联。HLA-DRB1是HLA-Ⅱ类基因DR亚区的一个功能基因座位。研究发现,HLA-DRB1与肿瘤的关系密切,许多肿瘤(乳腺癌、宫颈癌、头颈部恶性肿瘤等)细胞上发现了HLADRB1的异常表达,并且在不同种族及地域间存在较大的差 Major histocompatibility complex (MHC) is a highly polymorphic complex composed of a series of closely linked loci. Human MHC is also called human leukocyte antigen (HLA). HLA is involved in the immune response and is associated with various diseases. HLA-DRB1 is a functional locus of DR sub-region of HLA class II gene. The study found that, HLA-DRB1 and tumor closely, many tumors (breast cancer, cervical cancer, head and neck cancer, etc.) cells found abnormal expression of HLADRB1, and in different races and regions there is a big difference