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通过对TNF分子多个部位的修饰以及将TNF分子与其它物质连接可以改变TNF的生物学活性,从而有可能用分子生物学的方法合成一些抗瘤效应高、毒副作用低的TNF“异构体”并用于临床。
Through the modification of multiple sites of TNF molecules and the connection of TNF molecules with other substances, the biological activity of TNF can be changed, making it possible to synthesize some TNF “isoforms with high anti-tumor effect and low toxic side effects by molecular biology ”And for clinical use.