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本文选用 ICR 雄性小鼠,经腹腔分别注射不同剂量的~(125)I 及~(131)I,观察并比较它们对小鼠精子畸形发生率的影响及染毒后睾丸中放射性活度的变化。实验结果表明:(1)~(125)I 染毒后4—5周,0、185、370和555 kBq 各组精子畸形发生率分别为9.00‰、9.57‰、11.6‰及13.9‰;~(131)I 染毒后4—5周,上述各组精子畸形发生率分别为8.50‰、12.5‰、14.7‰和15.5‰;在相同注入量下,~(125)I 与~(131)I 诱发小鼠精子畸形发生率的差异各组均不显著(X~2检验,p>0.05)。(2)~(125)I、~(131)I 染毒后2h 至7天内,两者在睾丸中的放射性活度及变化规律相似,即在染毒后2h 达最高值,每克睾丸中~(125)I 和~(131)I 的放射性活度分别占初始注入量(370 kBq)的0.72％和0.50％,然后迅速下降,至一周时,仅分别占初始注入量的0.035％和0.011％。
In this study, ICR male mice were injected intraperitoneally with different doses of ~ (125) I and ~ (131) I, and their effects on the incidence of sperm deformity and the changes of radioactivity in testis . The experimental results showed that the incidences of sperm deformities were 9.00 ‰, 9.57 ‰, 11.6 ‰ and 13.9 ‰ respectively at 4-5 weeks, 0,185,370 and 555 kBq after (1) ~ (125) I exposure; The incidence of sperm deformity in the above groups was 8.50 ‰, 12.5 ‰, 14.7 ‰ and 15.5 ‰, respectively, after 4-5 weeks of exposure to 131 I. In the same dose, ~ (125) I and 131I induced There was no significant difference in the incidence of sperm deformity in mice (X ~ 2 test, p> 0.05). (2) ~ (125) I, ~ (131) I within 2h to 7 days after exposure, both in the testis of radioactivity and changes in the law similar to that at 2h after exposure to the highest value per gram of testis The radioactivity of ~ (125) I and ~ (131) I accounted for 0.72% and 0.50% of the initial injection (370 kBq), then decreased rapidly to only 0.035% and 0.011 %.