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目的探讨冠心病(CAD)严重度对心率变异性(HRV)的影响及其关系,为诊断CAD提供更多依据。方法选取CAD患者136例作为实验组,分别为SAP组、UAP组、NSTEMI组和STEMI组,每组34例,选取健康体检者34例作为正常对照组,所有入选对象于入院后24h内行24h动态心电图检查。结果 CAD患者HRV各时域指标SDNN、SDANN、SDNNIndex、rMSSD及PNN50明显低于正常人,而STEMI组各HRV指标明显低于NSTEMI组、UAP组和SAP组,NSTEMI组各HRV指标明显低于UAP组和SAP组,UAP组各HRV指标明显低于SAP组,P<0.01,有统计学意义。结论 HRV可作为一个无创性指标间接反映CAD严重度,为CAD的临床诊断提供依据。
Objective To investigate the influence of severity of coronary heart disease (CAD) on heart rate variability (HRV) and its relationship to provide more evidence for the diagnosis of CAD. Methods Thirty-six patients with CAD were selected as experimental group, SAP group, UAP group, NSTEMI group and STEMI group, 34 cases in each group. 34 healthy subjects were selected as normal control group. Electrocardiogram examination. Results The index of HRV in each time domain of CAD patients was significantly lower than that of normal subjects in SDNN, SDANN, SDNN Index, rMSSD and PNN50, while the HRV indexes in STEMI group were significantly lower than those in NSTEMI, UAP and SAP groups The indexes of HRV in group, SAP group and UAP group were significantly lower than those in SAP group, P <0.01, which were statistically significant. Conclusion HRV can indirectly reflect the CAD severity as a noninvasive index and provide the basis for the clinical diagnosis of CAD.