论文部分内容阅读
目的:评价口服磷酸钠盐用于结肠癌术后老年患者结肠镜检查前肠道准备的有效性、安全性及耐受性。方法:选取2011年9月1日至2011年12月31日间共116例行结肠镜检查的结肠癌术后老年患者,随机分组纳入试验组例和对照组,试验组口服磷酸钠盐进行肠道准备,对照组口服硫酸镁制剂。结肠镜检查术者单盲评价肠道准备的清洁度;患者在肠镜检查当日及检查结束1周后评价肠道准备的耐受度。并记录不良反应(安全性)。结果:试验组肠道准备的总满意率为82.1%(46/56),对照组为90.0%(54/60),两组之间无明显差异(P>0.05)。检查当10.7%的试验组患者和38.3%的对照组患者认为肠道准备过程难以耐受(P=0.001)。检查结束1周后7.1%的试验组患者和23.3%的对照组患者认为肠道准备过程难以耐受(P=0.003)。两组之间不良反应无显著性差异。结论:磷酸钠盐用于结肠癌术后老年患者的肠道准备,清洁效果和不良反应情况与硫酸镁制剂相似,但患者的耐受性却显著提高。
OBJECTIVE: To evaluate the efficacy, safety and tolerability of oral sodium phosphate for colon preparation in elderly patients with colon cancer after colonoscopy. Methods: A total of 116 elderly patients with colon cancer who underwent colonoscopy between September 1, 2011 and December 31, 2011 were enrolled in this study. Patients were randomly divided into experimental group and control group. Experimental group received oral sodium phosphate for intestine Road preparation, the control group oral magnesium sulfate preparations. The colonoscopy evaluated the cleanliness of the bowel preparation by a single blind. The patient was evaluated for bowel tolerance on the day of colonoscopy and one week after the end of the examination. And record adverse reactions (safety). Results: The total satisfactory rate of intestine preparation in trial group was 82.1% (46/56) and that in control group was 90.0% (54/60). There was no significant difference between the two groups (P> 0.05). Examination of 10.7% of patients in the test group and 38.3% of the control group considered that the intestinal preparation process was intolerable (P = 0.001). 7.1% of patients in the test group and 23.3% of the control group considered it difficult to tolerate the intestinal preparation one week after the end of the examination (P = 0.003). No significant difference between the two groups adverse reactions. CONCLUSIONS: Sodium phosphate is used in bowel preparation for postoperative elderly patients with colon cancer. The cleaning effect and adverse reactions are similar to those of magnesium sulfate preparations, but their tolerance is significantly improved.