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目的:探讨糖代谢因素对老年人良性前列腺增生症(BPH)临床进展的影响。方法:117例老年BPH患者将年龄≥62岁、PSA≥1.6ng/m L、PV≥31m L分为高进展性组(60人),其余为低进展性组(57人),分析比较两组间空腹血糖(FBS)、餐后2小时血糖(2h PBG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)等代谢性因素及BPH患者PV、血清前列腺特异性抗原(PSA)、国际前列腺症状评分(IPSS)、下尿路症状(LUTS)出现时间;用Logistic回归分析BPH临床进展性的危险因素。结果:BPH高进展性组与BPH低进展性组的FBS、2h PBG、Hb A1c、FINS相比有差异;且BPH高进展性组患者的PV明显大于BPH低进展性组患者,PSA值升高、IPSS分值增加;用Logistic逐步回归分析方法筛查BPH进展性危险因素,显示FBS、FINS为BPH患者临床进展的危险因素。结论:FBS、FINS可促使老年BPH患者的临床进展。
Objective: To investigate the effect of glucose metabolism on the clinical progress of benign prostatic hyperplasia (BPH) in the elderly. Methods: One hundred and seventy elderly BPH patients were divided into high progressive group (60 patients) and low progressive group (57 patients) with age≥62 years, PSA≥1.6ng / m L, PV≥31m L, FBS, 2h PBG, Hb A1c, FINS, HOMA-IR and other metabolic factors such as PV, serum prostate Specific antigen (PSA), International Prostate Symptom Score (IPSS) and Lower Urinary Tract Symptoms (LUTS) were recorded. Logistic regression was used to analyze the clinical risk factors of BPH. Results: The BPH patients with high progressive group had the same changes as FBS, 2h PBG, Hb A1c and FINS patients with BPH low progressive group. The patients with BPH advanced progressive group had significantly higher PV than those with BPH low progressive group, , IPSS score increased; using Logistic stepwise regression analysis of screening for progressive BPH risk factors, showing FBS, FINS for BPH patients with clinical risk factors. Conclusion: FBS and FINS can promote the clinical progress of elderly BPH patients.