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目的 观察应用三代头孢时发生抗生素相关性腹泻 (以下简称腹泻 )的因素及口服微生态制剂对其防治效果。方法 对照组 119例应用头孢曲松治疗时未同时用微生态制剂。观察组 2 19例在头孢曲松用药同时随机分组预防性给予微生态制剂 (乳酶生、双歧杆菌或双歧杆菌和酪酸梭菌二联活菌 )。结果 对照组中同年龄组头孢曲松用药剂量大于 6 0～ 80mg·kg-1 d-1易腹泻 (P =0 0 1) ;相同头孢曲松用药剂量下 ,小于 7岁者易腹泻 (P =0 0 19)。观察组腹泻的发生明显减少 (P =0 0 0 0 )。二联活菌效果较好 ,单用双歧杆菌活菌次之 (P1=0 0 2 1、P2 =0 0 14 )。腹泻发生后单纯应用微生态制剂难以见效。结论 头孢曲松用药剂量大、患儿年龄小易出现腹泻。发生腹泻后不停抗生素 ,用微生态制剂难以奏效。预防性应用且联合应用微生态制剂可以很好的预防腹泻
Objective To observe the factors of antibiotic-associated diarrhea (hereinafter referred to as diarrhea) and the effect of oral administration of probiotics on the prevention and treatment of the third generation cephalosporin. Methods 119 cases of control group ceftriaxone treatment without simultaneous use of probiotics. In the observation group, 19 cases were treated with ceftriaxone and prophylactic administration of probiotics (Lactobacillus, Bifidobacterium or Bifidobacterium and Clostridium butyricum viable) simultaneously. Results In the control group, ceftriaxone at the same age was predominately digested at a dose of 60-80 mg · kg -1 d -1 (P = 0 0 1). In the same dosage of ceftriaxone, diarrhea (P = 0 0 19). The incidence of diarrhea in the observation group was significantly reduced (P = 0 0 0 0). Bifidobacterium with good effect, single bifidobacteria live second (P1 = 0 0 2 1, P2 = 0 0 14). Simple application of probiotics after diarrhea difficult to effective. Conclusion Ceftriaxone large dose, children younger prone to diarrhea. Stop antibiotics after diarrhea, with probiotics difficult to work. Prophylactic and combined application of probiotics can prevent diarrhea