There have been reports for many years that the ionosphere is very sensitive to seismic effects, and the detection of ionospheric perturbations associated with earthquakes(EQs) attracts a lot of attention as a very promising candidate for short-term EQ prediction.In this review we present a possible use of VLF/LF (very low frequency(3-30 kHz)/low frequency(30-300 kHz)) radio sounding of seismo-ionospheric perturbations. In order to avoid the overlapping with my own previous reviews,we first show some pioneering results for the Kobe EQ and we try to present the latest results including the statistical evidence on the correlation between the VLF/LF propagation anomalies(ionospheric perturbations) and EQs(especially with large magnitude and with shallow depth),medium-distance(6-8 Mm) propagation anomalies,the fluctuation spectra of subionospheric VLF/LF data(the effect of atmospheric gravity waves,the effect of Earth’s tides,etc.),and the mechanism of lithosphere-atmosphere-ionosphere coupling.Finally,we indicate the present situation of this kind of VLF/LF activities going on in different parts of the globe and we suggest the importance of international collaboration in this seismo-electromagnetic study. There have been reports for many years that the ionosphere is very sensitive to seismic effects, and the detection of ionospheric perturbations associated with earthquakes (EQs) attracts a lot of attention as a very promising candidate for short-term EQ prediction. This review we present a possible use of VLF / LF (very low frequency (3-30 kHz) / low frequency (30-300 kHz)) radio sounding of seismo-ionospheric perturbations. In order to avoid the overlapping with my own recent reviews, we first show some pioneering results for the Kobe EQ and we try to present the latest results including the statistical evidence on the correlation between the VLF / LF propagation anomalies (ionospheric perturbations) and EQs (especially with large magnitude and with shallow depth), medium-distance (6-8 Mm) propagation anomalies, the fluctuation spectra of subionospheric VLF / LF data (the effect of atmospheric gravity waves, the effect of Earth’s tides, etc.), And the mechanism of lithosphere-atmosphere-ionosphere cou pling.Finally, we indicate the present situation of this kind of VLF / LF activities going on in different parts of the globe and we suggest the importance of international collaboration in this seismo-electromagnetic study.