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在28只麻醉大鼠,观察了牵拉心房和急性扩容时的肾效应。用5—7g的砝码牵拉大鼠右心房30min(n=6)时,尿量、尿钠和尿钾分别增加98％、127％和59％;牵拉左心房(n=4)所致的肾效应与牵拉右心房的基本相同。切断双侧迷走神经后,牵拉右心房的肾效应无明显改变。在切断迷走神经的大鼠,观察了双线结扎右心耳对急性扩容后肾效应的影响。急性扩容在假手术大鼠引起明显的利尿、钠尿和钾尿效应(P<0.01);而结扎右心耳的大鼠,钠尿效应约为假手术大鼠的一半,但尿量和尿钾排泄量与假手术组无明显异差。上述肾效应不受切断迷走神经的影响,因此不是通过容量感受性反射引起的。根据以上结果,我们推测,牵拉心房或急性扩容引起的尿量、尿铜和尿钾的增多,可能是心房钠尿因子释放增多所致,而结扎右心耳则导致释放入血流的心房钠尿因子减少。
In 28 anesthetized rats, the effects of arachnoid traction and acute dilation were observed. Urine volume, urinary sodium, and urinary potassium increased by 98%, 127% and 59%, respectively, in the right atrium of rats with a weight of 5-7 g for 30 min (n = 6) The induced renal effects and pull the right atrium is basically the same. After cutting off the bilateral vagus nerve, pulling the right atrium of the renal effect no significant change. In rats with vagotomy, the effects of double-ligation of the right atrial appendage on renal effects after acute dilatation were observed. Acute dilatation caused obvious diuretic, natriuretic and potassium-urinary effects in sham-operated rats (P <0.01), while the rats with ligation of the right atrial appendage had about half the natriuretic effect of sham-operated rats, but the urine output and urinary potassium Excretion and sham group no significant difference. The above renal effects are not affected by the vagus nerve cut off and are therefore not caused by a volume-sensitive reflex. Based on the above results, we hypothesize that the increase in urinary output, urinary copper and urinary potassium due to traction of the atrium or acute dilatation might be due to the increased release of atrial natriuretic factor, whereas the ligation of the right atrial appendage results in the release of atrial natriuretic Decreased urinary factor.