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血小板在机体的出凝血和炎性反应过程中发挥着重要作用,血小板输注可以及时止血,并有效减少红细胞和血浆的输注[1]。随着血小板成分输血的开展,临床血小板输注越来越普及,但由于其生理结构导致无法长期保存,且临床用量较大,医院常会出现血小板不足的情况,特别是稀有血型的紧缺问题[2]。这些临床血小板紧缺问题,迫使科学家一直在寻找制造血小板的方法。利用干细胞体外诱导分化生成血小板成为众多研究学者的研究热点,试图通过这种方法体
Platelets play an important role in the process of coagulation and inflammatory response in the body. Platelet transfusion can stop bleeding in time and effectively reduce the transfusion of red blood cells and plasma [1]. With the development of blood transfusion of platelet components, clinical platelet transfusion has become more and more popular, but because of its physiological structure, it can not be preserved for a long time and the clinical dosage is large, the hospital often has platelet insufficiency, especially the shortage of rare blood type [2 ]. These clinical shortage of platelets, forcing scientists have been looking for ways to create platelets. The use of stem cells in vitro induced differentiation of platelets has become the research focus of many researchers, trying to use this method body