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为探讨职业性苯中毒的早期监测指标，本实验对低于国家卫生标准的二个不同浓度下职业苯接触组的人群，测定了白细胞膜脂流动性（Ｌ），白细胞和血清丙二醛（ＭＤＡ）、血清超氧化物歧化酶（ＳＯＤ），丙氨酸转氨酶（ＡＬＴ）、硷性磷酸酶（ＡＫＰ）等生化指标以及白细胞（ＷＢＣ）、血小板（Ｐｔ）计数、血红蛋白（Ｈｂ）含量等传统指标；部分工人检测了尿液反，反－粘康酸（ｔ，ｔ－ＭＡ）含量。结果∶接触组的ＷＢＣ计数较对照组明显下降，接触组人群尿液ｔ，ｔ－ＭＡ显著升高，而白细胞膜脂流动性（Ｌ）及ＭＤＡ、ＳＯＤ、ＡＬＴ、ＡＫＰ在各组均未见明显改变。提示尿ｔ，ｔ－ＭＡ可作为长期低浓度苯接触人群的特异性监测指标，对于早期发现苯影响有着重要的临床意义
In order to explore the early monitoring indicators of occupational benzene poisoning, this study measured the fluidity (L) of leukocyte membrane lipids, leukocyte and serum malondialdehyde (MDA) in the crowd of benzene exposure group under two different concentrations below the national health standard MDA, ALT, AKP and other biochemical parameters such as white blood cell (WBC), platelet count (Pt) and hemoglobin (Hb) Indicators; some workers tested urine anti-trans-muconic acid (t, t-MA) content. Results: Compared with the control group, the WBC counts in the contact group were significantly decreased. The urine t-t and t-MA in the contact group were significantly increased, while the leukocyte membrane fluidity (L), MDA, SOD, ALT and AKP were not found in all groups Significant change. Urinary t, t-MA can be used as long-term low-concentration benzene exposure to the crowd of specific monitoring indicators for the early detection of benzene has an important clinical significance