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研究减少大剂量甲氨喋呤-四氢叶酸钙（ＨＤＭＴＸ－ＣＦ）疗法中ＣＦ用量的可行性。方法：对１７例病人的８６例次ＨＤＭＴＸ－ＣＦ采用两种不同的ＣＦ解救剂量，对ＨＤＭＴＸ常见的毒副作用一粘膜损害、肝、肾损害及骨髓抑制等进行观察对比。结果：在加强水化、碱化的条件下减少ＣＦ的解救剂量未增加以上各种毒性作用，病人的耐受性很好。结论：本文中所采用的减少ＣＦ剂量的ＨＤＭＴＸ－ＣＦ解救方案是切实可行的。
To investigate the feasibility of reducing the amount of CF in high-dose methotrexate-calcium tetrahydrofolate (HDMTX-CF) therapy. Methods: Eighty-six cases of HDMTX-CF in 17 patients were treated with two different doses of CF. The common side effects of HDMTX were mucosal damage, liver and kidney damage, and myelosuppression. Results: Reducing the rescue dose of CF under the condition of enhanced hydration and alkalization did not increase the above-mentioned various toxic effects, and the patient’s tolerance was very good. Conclusion: The HDMTX-CF rescue protocol with reduced CF dose used in this paper is feasible.