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近年来随着生物化学和分子生物学技术的发展,人们发现除了经典的肾素一血管紧张素系统(RAS)对机体的水、电解质等平衡进行调节外,在心血管系统还存在局部RAS,可自身合成、释放肾素和血管紧张素(AGT),在高血压、心肌缺血、心肌肥厚、心肌梗塞和心律失常等疾病的发生上具有重要作用。总结了经典和局部RAS的机制及作用,并对运动与RAS的关系进行综述。由于运动可激活RAS,我们是否可以间接地推测:在剧烈运动对心脏的影响中,RAS起到某种损害作用?因此对运动与RAS进行深入的研究有助于揭示大强度运动引发心脏损害的机制以及应用AⅡ转换酶抑制剂能否减轻心脏损害等问题,具有重大的实际意义。
In recent years, with the development of biochemistry and molecular biology techniques, it has been found that in addition to the regulation of the balance of water and electrolyte in the body by the classic renin-angiotensin system (RAS), there are also local RAS in the cardiovascular system Its own synthesis, release of renin and angiotensin (AGT), in hypertension, myocardial ischemia, myocardial hypertrophy, myocardial infarction and arrhythmia and other diseases play an important role. The mechanisms and roles of classical and local RAS were summarized, and the relationship between exercise and RAS was reviewed. Since exercise can activate RAS, can we indirectly infer that RAS plays a damaging role in the effects of strenuous exercise on the heart? Therefore, in-depth study of exercise and RAS will help reveal the mechanism of cardiac injury caused by intensive exercise and whether AII-converting enzyme inhibitors can reduce heart damage and other issues, which is of great practical significance.